|
KMID : 0377619670120040379
|
|
Korean Jungang Medical Journal
1967 Volume.12 No. 4 p.379 ~ p.385
|
|
|
Effect of Liver Injury on Serum and Liver Malic
|
|
|
|
|
Abstract
|
|
|
Male adult rabbit was subjected to investigate the interrelationship between serum and liver malic dehydrogenase activity following experimental liver injury.
Liver injury was performed by 2 kinds of operation, one was partial ligation and the other was partial hepatectomy at 1/3 portion of left liver lobe. One 2.3 and 4 days after operation, 10 rabbits out of each group were sacrificed respectively and remaining liver tissue was taken out for enzyme assay.
Blood drawn before operation and resected liver tissue by partial hepatedctomy were used for control experiment.
Matic dehydrogenase activity was determined by the method of Porter(45) and Bodansky (46) using serum and 10xliver homogenate. The result of this investigation was as follow.
1. The serum malic dehydrogenase activity of liver injured rabbit was increased significantly and reached maximum peak at the next day after operation (ligated group; 257.5% and resected group; 278.1% of control) followed by sharp decrease and reached around the preinjured state.
2. The liver malic dehydrogenase activity of liver injured rabbit was also increased and reached maximum peak at the next day after operation (ligated group: 227.5%, resected group, 268.5%) followed by sharp decrease and returned to preinjured state
3. From the data; thus obtained, the author concluded that the increase of serum malic dehydrogenase of liver injured animal was originated in the liver enzyme which was increased compensatorily due to liver regeneration but not due to the leakage out of necrotized liver tissue.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|